liang.jpg - 54220 Bytes Chun Liang
Assistant Professor of Botany
Affiliate in the Department of Computer Science and Systems Analysis
Ph.D. (1999) University of Georgia
350 Pearson Hall
(513) 529-2336
Email:
liangc@muohio.edu
Webpage:http://www.conifergdb.org

Bioinformatics; plant genomics, proteomics and metabolomics; biological databases and data mining.



Research Interests:

My general research interests primarily focus on use of various computational tools, including development of new algorithms, software and databases, to address biological questions related with plant genomics, proteomics and metabolomics at different levels from individuals, populations, to ecosystems. While emphasizing traditional and experimental biology, my research is focused on computational biology by conducting biological experimentations in silico.

Currently, I am interested in transcriptome analysis for novel gene discovery and gene expression profiling study in plants using various bioinformatics solutions. The ongoing projects center in data processing, data integration and data mining for Expressed Sequence Tags (ESTs) and cDNA-based microarray. Particularly, I want to understand how gene expression profile changes in response to different genotypes, environmental conditions and developmental stages. Also, I am developing new algorithms, database infrastructures and software systems for clustering ESTs and exploring various EST features, including 3’ and 5’ UTR, SSR, SNP, protein coding domains, splice variants and so on.




Selected Publications:

Liang, C., Liu, Y., Liu, L., Davis, A.C., Shen, Y. and Q.Q. Li (2008) ESTs with cDNA termini - previously overlooked resources for gene annotation and transcriptome exploration in Chlamydomonas reinhardtii. GENETICS, (in press).

Liang, C., Wang, G., Liu, L., Ji, G., Fang, L., Liu, Y., Carter, K., Webb, J.S., Dean, J.F. ConiferEST: an integrated bioinformatics system for data reprocessing and mining of conifer expressed sequence tags (ESTs). BMC Genomics 2007, 8:134. Article URL

Liang, C., Wang, G., Liu, L., Ji, G., Liu, Y., Chen, J., Webb, J.S., Reese, G., and Dean, J.F. (2007) WebTraceMiner: a web service for processing and mining EST sequence trace files. Nucleic Acids Research, doi:10.1093/nar/gkm299. Article URL

Liang, C., Sun, F., Wang, H., Qu, J., Freeman, R.M., Jr., Pratt, L.H., Cordonnier-Pratt, M.M. 2006. MAGIC-SPP: a database-driven DNA sequence processing package with associated management tools. BMC Bioinformatics, 7:115. [DOI:10.1186/1471-2105-7-115]. Article URL

Pratt, L.H., Liang, C., Shah, M., Sun, F., Wang, H., Reid, S.P., Gingle, A.R., Paterson, A.H., Wing, R., Dean, R., Klein, R., Nguyen, H.T., Ma, H.-M., Zhao, X., Morishige, D.T., Mullet, J.E., and Cordonnier-Pratt, M.-M. 2005. Sorghum Expressed Sequence Tags Identify Signature Genes for Drought, Pathogenesis and Skotomorphogenesis from a Milestone Set of 16,801 Unique Transcripts. Plant Physiology, 139:869-884.

Lorenz, W.W., Sun, F., Liang, C., Kolychev, D.S., Wang, H., Zhao, X., Cordonnier-Pratt, M.-M., Pratt, L.H., and Dean, J.F.D. 2005. Water stress-responsive genes in loblolly pine (Pinus taeda) roots identified by analysis of expressed sequence tag libraries. Tree Physiology, 26:1-16.

Cordonnier-Pratt, M.-M., Liang, C., Wang, H., Kolychev, D.S., Sun, F., Freeman, R., Sullivan, R., and Pratt, L.H. 2004. MAGIC Database and interfaces: an integrated package for gene discovery and expression. Comparative and Functional Genomics, 5(3):268-275.

Liang, C., McClendon, R., and Das, K.C. 2003. Prediction of Microbial Activity During Biosolid Composting using Artificial Neural Network. Transactions of the ASAE, 46(6):1713-1719.

Liang, C., Das, K.C., and McClendon, R. 2003. The influence of temperature and moisture content regimes on microbial activity during biosolids composting. BioResource Technology, 86:131-137.

Liang, C.
, Filion, L., and Cournoyer, L. 1997. Wood structure of biotically and climatically induced light rings in eastern larch (Larix laricina). Canadian Journal of Forest Research, 27:1538-1547.

Liang, C., Lin, Z., and Kong, G. 1997. Photosynthesis-light response characteristics of subtropical tree species seedlings under different irradiances. Chinese Journal of Applied Ecology, 8(1): 7-11

Kong, G., Liang, C., and Hong, Z. 1993. DingHuShan Biosphere Reserve: ecological research history and perspective, Science Press, Beijing, New York, 38pp.

Liang, C., and Huang, H. 1992. Tree-ring element analysis of Korean Pine (Pinus koraiensis Sieb. et Zucc.) and Mongolian Oak (Quercus mongolica Fisch. ex Turcz.) from Changbai Mountain, Northeast China. Trees: structure and function, 6(2):103-108



Return to Faculty List