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Infrared and Raman Microspectroscopy, forensics, nanotechnology, biomedical Scientist are being asked to identify and analyze ever smaller amounts of material. A solution to this problem involves the use of molecular microspectroscopy, which provides unique molecular fingerprints of isolated particles, or particles embedded in matrices. The size of the particulate that can be analyzed is limited, in part, to the analytical wavelengths employed for analyses (typical 1 to 14 micrometers) and instrumental design. Research interests are, therefore, directed toward the development and applications of molecular microspectroscopies for chemical analysis and materials characterization. Specific areas involve the design, construction and characterization of novel Raman, luminescence and infrared microscopes with the goal of overcoming the wavelength limitation. Future goals are to employ the techniques in a quantitative capacity. More general areas involve methods development for the use of these techniques in a wide variety of disciplines. References:
Instrument Development "Prism Based Infrared Spectrographs using Modern-Day Detectors", Z. Keltner, K. Kayima, A. Lanzarotta, L. Lavalle, M. Canepa, A. E. Dowrey, G. M. Story, C. Marcott and A. J. Sommer, Appl. Spectrosc., 61(9), 909-915 (2007).
"Attenuated Total Internal Reflection (ATR) Raman Microspectroscopy", L. Tisinger and A. J. Sommer, Microscopy and Microanalysis 10 (Suppl. 2) 1318-1319 (August 2004).
"Attenuated Total Internal Reflectance Infrared Microspectroscopy as a Detection Technique for Capillary Electrophoresis", B. M. Patterson, N. D. Danielson and A. J. Sommer, Anal. Chem., 76(13), 3826-3832 (2004).
"Attenuated Total Internal Reflectance Infrared Microspectroscopy as a Detection Technique for High Performance Liquid Chromatography", B. M. Patterson, N. D. Danielson and A. J. Sommer, Anal. Chem., 75(6), 1418-1424 (2003).
“Attenuated Total Internal Reflection Infrared Mapping Microspectroscopy Using an Imaging Microscope", A. J. Sommer, L. G. Tisinger, C. M. Marcott and G. Story, Appl. Spectrosc., 55(3), 252-256 (2001).
Biomedical Investigations
"Histopathology and Surgical Anatomy of Patients with Primary Hyperparathyroidism and Calcium Phosphate Stones", A. E. Evan, J. E. Lingeman, F. L. Coe, N. L. Miller, S. B. Bledsoe, A. J. Sommer, J. C. Williams, Y. Shao and E. M. Worcester, Kidney International 74, 223-229 (2008).
"Renal Calcinosis and Stone Formation in Mice Lacking Osteopontin, Tamm-Horsfall Protein or Both", L. Mo, L. Liaw, A. P. Evan, A. Sommer, J. Lieske and X.-R. Wu, AJP: Renal Physiology, 293, F1935-F1943 (2007).
"Analysis of Urinary Calculi Using an Infrared Microspectroscopic Surface Reflectance Imaging Technique", J. C. Anderson, J. C. Williams, Jr., A. P. Evan, K. W. Condon, and A. J. Sommer, Urol. Res. 35:41-48 (2007).
"Renal Histopathology of Stone-forming Patients with Distal Renal Tubular Acidosis", A. P. Evan, J. Lingeman, F. Coe, Y. Shao, N. Miller, B. Matlaga, C. Phillips, A. Sommer and E. Worcester, Kidney International 71, 795-801 (2007).
"Continuous Infusion of Oxalate by Minipumps Induces Calcium Oxalate Nephrocalcinosis", S. R. Marengo, D. H.-C. Chen, A. P. Evan, A. J. Sommer, N. T. Stowe, D. G. Ferguson, M. I. Resnick, and G. T. MacLennan, Urological Research 34(3), 200-210 (2006). |
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This page was last modified on August 27, 2008. |